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Tuesday, July 21, 2020 | History

2 edition of A physiologically based kinetic model of rat and mouse gestation found in the catalog.

A physiologically based kinetic model of rat and mouse gestation

A physiologically based kinetic model of rat and mouse gestation

disposition of a weak acid

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  • 5 Currently reading

Published by U.S. Environmental Protection Agency in [Washington, D.C.? .
Written in English

    Subjects:
  • Rats -- Pregnancy -- Mathematical models,
  • Mice -- Pregnancy -- Mathematical models,
  • Developmental toxicology -- Mathematical models

  • Edition Notes

    StatementEllen J. O"Flaherty ... [et al.]
    ContributionsO"Flaherty, Ellen J., 1936-, United States. Environmental Protection Agency
    The Physical Object
    FormatMicroform
    Paginationp. 245-256
    Number of Pages256
    ID Numbers
    Open LibraryOL14956307M

    “A PHYSIOLOGICALLY BASED KINETIC-MODEL OF RAT AND OUSE GESTATION - DISPOSITION OF A WEAK ACID.” Toxicology and Applied Pharmacology. (2), – ; Osinski M. A., Seifert T. R., Cox B. F., Gintant G. A. (). “An improved method of evaluation of drug-evoked changes in gastric emptying in mice.”Cited by: Physiologically based pharmacokinetic modeling is a mathematical modeling technique for predicting the absorption, distribution, metabolism and excretion of synthetic or natural chemical substances in humans and other animal species. PBPK modeling is used in pharmaceutical research and drug development, and in health risk assessment for cosmetics or general chemicals. PBPK models strive to be .

      The purpose of this study was to determine the in vitro Michaelis–Menten kinetic parameters involved in the initial step in the metabolism of B[a]P and DBC across multiple species using liver microsomes obtained from male Sprague-Dawley rats, naïve and pregnant female BSFI/J mice, and female human. These species were selected due to the volume of previous literature on B[a]P in the rat Cited by: A physiologically based kinetic model of rat and mouse gestation: disposition of a weak acid. O'Flaherty EJ, Scott W, Schreiner C, Beliles RP. Toxicol Appl Pharmacol, (2), 01 Feb Cited by: 41 articles | PMID:

    To better understand the toxicokinetics of ATR and to fill the need for a mouse model, a physiologically based pharmacokinetic (PBPK) model for ATR and its main chlorotriazine metabolites (Cl-TRIs) desethyl atrazine (DE), desisopropyl atrazine (DIP), and didealkyl atrazine (DACT) was developed for the adult male C57BL/6 mouse. (). A physiologically based kinetic model of rat and mouse gestation: disposition of a weak acid. (). A Physiologically based pharmacokinetic model for methyl mercury in the pregnant rat and fetus. (). A review of developmental aspects of cytorcrome P ().


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A physiologically based kinetic model of rat and mouse gestation Download PDF EPUB FB2

A physiologically based toxicokinetic model of gestation in the rat and mouse has been developed. The model is superimposed on the normal growth curve for nonpregnant females.

It describes the entire gestation period including the period of by:   A physiologically based toxicokinetic model of gestation in the rat mouse has been developed.

The model is superimposed on the normal growth curve for nonpregnant females. It describes the entire gestation period including organogenesis. Get this from a library.

A physiologically based kinetic model of rat and mouse gestation: disposition of a weak acid. [Ellen J O'Flaherty; United States. Environmental Protection Agency.;]. A physiologically based toxicokinetic model of gestation in the rat and mouse has been developed.

The model is superimposed on the normal growth curve for nonpregnant females. Blood and tissue data were analyzed using the extrapolated PBPK model that was modified to simulate 2-ME and 2-MAA kinetics in maternal plasma and total embryo tissues in pregnant rats.

The original mouse model was simplified by combining the embryos Cited by: The basic structure follows the physiologically based kinetic model of rat and mouse gestation developed by O'Flaherty et al. The brain compartment was added to the model since it is considered to be one of the target organs of BPA.

The yolk sac and chorioallantoic placentas were modeled as a single placenta for by: Recently, we defined a physiologically based biodynamic (PBBD) model to predict the dose-dependent DNA binding of estragole in rat liver (15) by extending the previously published physiologically.

A physiologically based toxicokinetic model of gestation in the rat and mouse has been developed. The model is superimposed on the normal growth curve for nonpregnant females.

It describes the. In rodents, safrole is metabolized in the liver through phase I metabolism mediated by cytochrome P Based on validated physiologically-based kinetic model of safrole metabolism for rat and.

PBPK models developed for a particular gestation day have often focused on latter periods of gestation in mice, rats and rabbits, and have relied on a single set of physiological parameter estimates for the mother and the fetus or embryo (Olanoff and Anderson,Gabrielsson and Paalzow,Gabrielsson et al.,Gabrielsson et al.,Gabrielsson and Groth,Terry et al.,Cited by: 3.

Physiologically based pharmacokinetics (PBPK) Allometric scaling is widely used to predict human pharmacokinetic parameters from preclinical species, and many different approaches have been proposed over the years to improve its predictive performance.

A physiologically based kinetic model of rat and mouse gestation: disposition of a weak acid. Toxicol Appl Pharmacol. Feb; (2)– Boike GM, Deppe G, Young JD, Malone JM, Jr, Malviya VK, Sokol RJ. Chemotherapy in a pregnant rat model. fluorouracil: nonlinear kinetics and placental transfer.

Gynecol by:   O’Flaherty EJ, Scott W, Schreiner C, Beliles RP () A physiologically based kinetic model of rat and mouse gestation: disposition of a weak acid. Toxicol Appl Pharmacol – Article; PubMed; Google ScholarCited by: Since their inception in pharmaceutical applications, physiologically-based kinetic (PBK) models are increasingly being used across a range of sectors, such as safety assessment of cosmetics, food additives, consumer goods, pesticides and other chemicals.

Such models can be used to construct organ-level concentration-time profiles of by: 4. Physiological Parameter Values for Physiologically Based Pharmacokinetic Models Ronald P. Brown, Michael D. Delp, Stan L. Lindstedt, Lorenz R. Rhomberg, and Robert P. Beliles Toxicology and Industrial Health 4, Cited by: A kinetic model ofregulation ofthe deoxyribonucleoside triphosphate pool composition.

Pharmacol Ther (). A new method for determining allowable daily intakes. A physiologically based kinetic model of rat and mouse gestation: disposition of a weak : R J Kavlock and R W Setzer.

Central nervous system (CNS) drug disposition is dictated by a drug’s physicochemical properties and its ability to permeate physiological barriers. The blood–brain barrier (BBB), blood-cerebrospinal fluid barrier and centrally located drug transporter proteins influence drug disposition within the central nervous system.

Attainment of adequate brain-to-plasma and cerebrospinal fluid-to Cited by: @article{osti_, title = {Physiologically based Pharmacokinetic Modeling of 1,4-Dioxane in Rats, Mice, and Humans}, author = {Sweeney, Lisa M and Thrall, Karla D and Poet, Torka S and Corley, Rick and Weber, Thomas J and Locey, B J and Clarkson, Jacquelyn and Sager, S and Gargas, M L}, abstractNote = {ABSTRACT 1,4-Dioxane (CAS No.

) is used primarily as a solvent or as a. The present study defines a physiologically based biokinetic (PBBK) model for the alkenylbenzene estragole in rat based on in vitro metabolic parameters determined using relevant tissue fractions, in silico derived partition coefficients, and physiological parameters derived from the literature.

The effects of perchlorate on the incorporation of iodide into thyroid hormones have been studied for more than 40 years in many species and under varying exposure conditions. Nevertheless, the database for this drinking water contaminant is still incomplete, particularly with regard to human developmental by:.

A physiologically based kinetic model of rat and mouse gestation: disposition of a weak acid. Toxicol Appl Pharmacol. ; – OpenUrl CrossRef PubMedCited by: Gray DG. A physiologically based pharmacokinetic model for methyl mercury in the pregnant rat and fetus. Toxicol Appl Pharmacol. May; (1)– Terry KK, Elswick BA, Welsch F, Conolly RB.

Development of a physiologically based pharmacokinetic model describing 2-methoxyacetic acid disposition in the pregnant by:   The mode of action for the mouse-specific uterine tumors is not definitively known and could involve parent chemical and/or metabolite(s).

A physiologically based pharmacokinetic (PBPK) model for chloroethane disposition in the rat was developed previously, but no such models have been described for mice or by: 9.